Yamamoto Research’s Zinc is a zinc supplement in the picolinate form, characterised by excellent bioavailability, unlike more common forms of zinc. Zinc is an essential micronutrient for the body: it is involved in DNA synthesis, immune function, protein synthesis, cell division and wound healing, has antioxidant effects and provides protection against viruses, bacteria and fungi. This valuable mineral also contributes to the production of thyroid hormones (a lack of zinc prevents the conversion of T4 into T3), insulin and thymulin, and participates in the synthesis of male sex hormones such as testosterone. It also helps keep the the skin, hair and nails healthy and is crucial for development and growth, especially in children.
Zinc is an essential trace element that is often underestimated, despite the fact that the human body contains about 2 grams of it, and is involved in more than 300 enzymes that participate in DNA/RNA synthesis, regulation of growth and development processes, and immune, digestive and metabolic function. The enzyme carbonate dehydratase, in particular, enables the body to eliminate the carbon dioxide produced in the tissues. Zinc is also important for the constitution of collagenases and the regulation of genome transcription processes, cell signalling and hormone release, thus enhancing insulin activity.
What are the symptoms of Zinc deficiency?
Zinc deficiency can cause several symptoms. Here are some of the most common:
- Loss of appetite;
- Weight loss;
- Fatigue and weakness;
- Growth and development problems in children;
- Wound healing difficulties;
- Changes in taste and smell;
- Hair loss;
- Dry, scaly skin;
- Fertility problems;
- Recurrent infections.
Who is most at risk of developing a zinc deficiency? For whom is Zinc recommended?
- Children and adolescents;
- Subjects suffering from malnutrition or anorexia nervosa;
- Individuals with type I and type II diabetes, diseases that increase urinary zinc excretion;
- Individuals with chronic diarrhoea or bowel disease characterised by inflammation and/or malabsorption like Crohn's disease or Coeliac disease;
- Alcoholics, especially those with cirrhosis of the liver;
- Athletes subjected to intense endurance work with profuse sweating;
- Individuals on medication with tetracyclines, quinolones, bisphosphonates, chelating agents, anticonvulsants and diuretics;
- Individuals taking iron and calcium supplements, which can significantly reduce zinc absorption;
- Strict vegans who eat large amounts of cereals and pulses: the phytate content of these foods interferes with and drastically reduces zinc absorption.
Is Zinc really useful for counteracting common cold symptoms?
Zinc supplements are often used to treat colds and many studies have shown that zinc can actually block the replication of rhinoviruses, which are responsible for about 50% of colds. Zinc interferes with the reproduction of cold viruses in the nasal mucosa, thereby preventing their development and counteracting cold symptoms. If taken as soon as the first symptoms appear, zinc can significantly reduce healing times and cold symptoms. This has been scientifically proven in several studies.
Is it true that zinc plays a role in reproductive health and fertility?
Research has shown that maintaining adequate zinc levels in the body may be associated with higher testosterone levels and improved sperm health. Conversely, a zinc deficiency can result in reduced testosterone production in men. Studies have shown that zinc supplementation can increase serum testosterone levels, especially in men with low initial concentrations. Zinc supplementation can also preserve testosterone levels, which might otherwise decrease, after strenuous exercise, especially of the aerobic type.
I have heard that Zinc can also help in cases of PCOS. Is it true?
PCOS (polycystic ovary syndrome) is an endocrine condition that affects women of childbearing age and can cause hormone dysfunction, irregular periods, weight gain and infertility. Several studies have suggested that zinc may play a positive role in the management of PCOS-related symptoms. More specifically, a study published in the journal 'Biological Trace Element Research' showed that women with PCOS have lower zinc levels than healthy women, and that zinc supplementation can improve hormone levels and ovarian function and reduce the severity of acne. A paper published in the ‘Journal of Research in Medical Sciences’ suggested that zinc supplementation may improve the lipid profile and reduce the risk of heart disease in women with PCOS, and the element also seems to contribute to the regulation of the menstrual cycle. Serum zinc levels during the luteal phase (approximately 2 weeks before a period) are significantly lower than during the follicular phase, and have also been seen to be lower in women with PMS (pre-menstrual syndrome).
Scientific references
Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008 May-Jun;14(5-6):353-7. doi: 10.2119/2008-00033.Prasad. PMID: 18385818; PMCID: PMC2277319.
Wessels I, Fischer HJ, Rink L. Dietary and Physiological Effects of Zinc on the Immune System. Annu Rev Nutr. 2021 Oct 11;41:133-175. doi: 10.1146/annurev-nutr-122019-120635. Epub 2021 Jul 13. PMID: 34255547.
Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatol Surg. 2005 Jul;31(7 Pt 2):837-47; discussion 847. doi: 10.1111/j.1524-4725.2005.31729. PMID: 16029676.
Allouche-Fitoussi D, Breitbart H. The Role of Zinc in Male Fertility. Int J Mol Sci. 2020 Oct 21;21(20):7796. doi: 10.3390/ijms21207796. PMID: 33096823; PMCID: PMC7589359.
Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013 Feb;18(2):144-57. PMID: 23914218; PMCID: PMC3724376.
Foster M, Samman S. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients. 2012 Jul;4(7):676-94. doi: 10.3390/nu4070676. Epub 2012 Jul 4. PMID: 22852057; PMCID: PMC3407988.
Kogan S, Sood A, Garnick MS. Zinc and Wound Healing: A Review of Zinc Physiology and Clinical Applications. Wounds. 2017 Apr;29(4):102-106. PMID: 28448263.
