SetriBol Setria®

60 Capsules

Eliminate toxins and protect yourself against oxidative stress thanks to the King of Antioxidants molecule.

  • Molecule with a potent antioxidant action;
  • Counteracts free radicals and helps remove toxins;
  • Promotes liver and gastrointestinal function;
  • 250 mg of Setria®-quality reduced L-glutathione per capsule;
  • Promotes the regeneration and reactivation of other antioxidants.
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Special Price £30.89 Regular Price £38.61 -20%
The product expires on 30/06/2027
Immediate availability Express delivery 1-3 days
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Yamamoto® Nutrition’s Setria® SetriBol is a dietary supplement that provides 250 mg per daily dose of Setria® L-Reduced Glutathione. Glutathione is a potent antioxidant molecule that plays a key role in protecting the body against oxidative stress and the action of free radicals and is able to protect the hepatocytes against toxic molecules that can cause liver damage.

Glutathione is a ubiquitous molecule, i.e. one that is present throughout our body, but that is particularly concentrated in the liver, where it protects liver cells against toxic molecules: in this case, Glutathione “binds” to and neutralises toxic metabolites. Reduced glutathione is in fact able to surrender its hydrogen (H+), which acts as an acceptor of electrons (e-) from reactive oxygen molecules, i.e. free radicals. At this point, having eliminated the danger caused by free radicals, glutathione can regain its antioxidant activity and return to its reduced form. Glutathione’s ability to continually regenerate itself is the reason why it is considered the most powerful antioxidant in the human body. The molecule's biological functions support its clinical utility in several situations, foremost among them its ability to protect the liver against the action of toxic substances.

Why is the effect of Glutathione so important?

Twenty-four hours a day, seven days a week, free radicals are busy attacking our bodies at cell level. Scientists have discovered that this constant onslaught has detrimental effects on health and well-being in general, including the health and ageing of our tissues. Fighting the damage caused by free radicals seems to enable us to age better and live healthier lives, which is why it is important to ensure our bodies optimal levels of glutathione, a molecule capable of effectively counteracting oxidative stress.

How can Setria® SetriBol help your body fight free radicals?

Eating, exercising and even breathing are actions that can result in the formation of free radicals. Once formed, these molecules attack the body at cell level, stealing electrons from other molecules and triggering a chain reaction. SetriBol provides the body with reduced Glutathione, which binds to and neutralises free radicals.

Why is glutathione known as the ‘Master antioxidant' or the ‘King of antioxidants’?

Glutathione not only neutralises free radicals, it is also capable of reactivating other antioxidant molecules, like vitamins C and E. Normally, once antioxidants (e.g. vitamin C and vitamin E) have done their job by inactivating free radicals, they become unstable radicals themselves. Glutathione helps to recycle these molecules, restoring their function and extending their ability to attack free radicals, which is why Glutathione is considered the 'master' or 'King' molecule of all the body’s antioxidants.

How does Setria® SetriBol help eliminate toxins?

Glutathione supports the function of the liver, kidneys, gastrointestinal tract and intestines, the body's major detoxification pathways.

It acts on two different fronts:

  1. It helps eliminate toxins, ingested chemicals and potential carcinogens that the body has already absorbed;

  2. It intercepts and neutralises toxins in the gastrointestinal tract before they are absorbed.

Why can Setria® SetriBol also be useful for athletes?

Scientific research seems to suggest that Setria® glutathione facilitates Nitric Oxide (NO) production when combined with L-Citrulline and when used in endurance performance. **Setria® also appears to help maintain high NO levels, which may reduce fatigue and speed recovery.

Setria® SetriBol can therefore aid strength training by maintaining increased nitric oxide production after a training session.

**Patent Pending

Scientific references
Averill-Bates DA. The antioxidant glutathione. Vitam Horm. 2023;121:109-141. doi: 10.1016/bs.vh.2022.09.002. Epub 2023 Jan 13. PMID: 36707132.

Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. doi: 10.1007/s00394-014-0706-z. Epub 2014 May 5. PMID: 24791752.

Gérard-Monnier D, Chaudiere J. Métabolisme et fonction antioxydante du glutathion [Metabolism and antioxidant function of glutathione]. Pathol Biol (Paris). 1996 Jan;44(1):77-85. French. PMID: 8734304.

Jones DP. Redefining oxidative stress. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1865-79. doi: 10.1089/ars.2006.8.1865. PMID: 16987039.

Meister A. Glutathione metabolism and its selective modification. J Biol Chem. 1988 Nov 25;263(33):17205-8. PMID: 3053703.

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Nutritional information
Nutrition information Per daily dose (1 capsule)
   
Reduced L-Glutathione (Setria®) 250 mg
   
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Ingredients

reduced L-glutathione (Setria®), capsule (gelatine), bulking agent: cellulose; anti-caking agents: silicon dioxide, magnesium salts of fatty acids.

SETRIA® is a registered trademark of KYOWA HAKKO BIO CO., LTD.
Warnings
Do not exceed the recommended daily dose. Food supplements should not be used as a substitute of a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of reach of young children.
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Directions and intake
Take 1 capsule once a day with a glass of water.
Our Advice

We recommend taking SetriBol as part of your morning routine. It is important to take Glutathione after the recovery processes that normally take place in the body during the night, because endogenous Glutathione levels are naturally lower in the morning as soon as we wake up. We do not recommend taking Setria® SetriBol immediately after working out, because at this stage, although free radical production is high, the body undergoes physiological adaptations that must not be disrupted. It is always best to take antioxidant molecules some time before or after a workout.

Frequently asked questions

What role does glutathione play in liver detoxification?

Glutathione plays a key role in liver detoxification, because it is involved in numerous processes that rid the body of toxic substances. The liver is the main organ involved in detoxifying the body of chemicals and drugs: these compounds are metabolised through a series of enzymatic reactions that make them more water-soluble and therefore easily eliminated through urine or faeces.

Glutathione is an essential cofactor for two important enzymes involved in this detoxification process: glutathione S-transferase (GST) and glutathione peroxidase (GPx). GST is involved in the conjugation of toxic substances with glutathione, which increases their solubility and promotes their elimination from the body. GPx, on the other hand, is an antioxidant enzyme that uses glutathione to neutralise free radicals and other oxidising agents that can damage liver cells. In addition, glutathione plays an important role in governing the liver's redox balance, thereby protecting liver cells from oxidative damage caused by the reactive oxygen species (ROS) produced during the detoxification process. These ROS can damage DNA, proteins and cell lipids and cause inflammation and cellular damage.

How can Glutathione help prevent cellular ageing?

Glutathione can help prevent cellular ageing through its antioxidant action and its ability to protect cells from the damage caused by free radicals. It is also involved in numerous cell processes that help to prevent cellular ageing, such as regulating the cell cycle, protecting DNA from mutations and promoting the repair of damaged DNA. Nevertheless, the level of glutathione in the body tends to decrease with age, consequently making the cells more prone to oxidative damage and contributing to cellular ageing. Maintaining an adequate level of glutathione in the body is therefore important for preventing or slowing cellular ageing.

What are the consequences of a glutathione deficiency in the body?

A glutathione deficiency can have several negative consequences for the body's health and well-being, because it impairs immune system function, increases oxidative stress, causes liver damage, reduces the capacity to repair DNA and increases sensitivity to drugs and toxic substances. Therefore, maintaining an adequate level of glutathione in the body through a balanced diet, regular exercise and intake of food supplements, if necessary, can help prevent or reduce the risk of these negative consequences.

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Why choose it?

Why choose our supplement:

  • A very potent molecule with antioxidant action, considered the 'Master Antioxidant' of the entire human body;
  • Counteracts the detrimental action of free radicals and helps remove toxins;
  • Promotes liver and gastrointestinal function;
  • 250 mg of Setria®-quality reduced L-glutathione per capsule;
  • Supports the regeneration and reactivation of other antioxidants, such as vitamins C and E;
  • Ingredients of the highest quality and safety;
  • Produced entirely in Italy.
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SetriBol Setria® - Sticky
SetriBol Setria®
Special Price £30.89 Regular Price £38.61 -20%