30 tablets

It lowers blood cholesterol levels and supports your heart’s health.

  • It contributes to the maintenance of normal blood cholesterol levels;
  • It promotes normal blood circulation and regular blood pressure;
  • Based on Olecol® olive extract, fermented red rice, gamma oryzanol and coenzyme Q10;
  • Supports heart and liver health;
  • Supports carbohydrate and lipid metabolism.
The product expires on 31/05/2026
Immediate availability Express delivery 1-3 days

From the constant research of the Yamamoto® Research R&D team comes Coletix, a dietary supplement containing Olecol®-certified olive tree extract, fermented red rice (Monascus purpureus), gamma oryzanol and supplemented with coenzyme Q10, which, thanks to the synergy of the active ingredients contained, contributes to the maintenance of normal blood cholesterol levels, supports good blood circulation and the regularity of arterial pressure. Coletix provides 58 mg/daily dose of fermented red rice titrated at 2.76% in total monacolin (2.76 mg per daily dose, in compliance with the new European regulations on the use of Monacolin K).

Cardiovascular diseases are nowadays among the leading causes of disability and mortality in Western and developing countries, and are favoured by unhealthy lifestyles, unbalanced diet, excessive “junk food”, little or no physical activity, and smoking. The main factors influencing propensity to cardiovascular disease and disorders are cholesterol imbalance (hypercholesterolaemia), hypertriglyceridaemia, hypertension, diabetes and insulin resistance, as well as obesity. Specifically, it is a good idea to keep an eye on the entire lipid balance in order to guard against the formation of atherosclerotic plaques along the walls of the blood vessels, which are favoured by inflammation and hypertension, will potentially clog the vessels and cause very serious consequences on the cardiovascular system.

Coletix is the product Yamamoto® Research developed to promote and support good blood circulation, heart health and maintain normal levels of triglycerides and cholesterol in the blood. A titrated and standardised plant extract was chosen for the formulation, which allows the natural active ingredients to remain qualitatively and quantitatively constant, ensuring the product's stability, bioavailability and efficacy. The product has the following synergies:

  • Olecol® olive extract;

  • Fermented red rice;

  • Gamma oryzanol;

  • Coenzyme Q10.

In detail, Monacolin K from fermented red rice is a molecule belonging to the group of Monacolins, which originates from the fermentation of the common red cooking rice Oryza sativa through the action of the yeast Monascus purpureus, also known as 'red yeast, which gives it its characteristic colour. Having always been used in oriental cooking as a substitute for vinegar and as a health agent, the fermentation of this rice makes it possible to obtain numerous substances, the monacolines, which have a cholesterolaemic effect. Indeed, Traditional Chinese Medicine suggests the consumption of fermented red rice to cure circulatory disorders and also in cases of gastrointestinal discomfort, but the discovery of the molecule to which most of the beneficial characteristics are attributed dates back to 1979. In that year, Professor Aika Endo, while studying the fermentation of “red yeast”, discovered that a metabolite produced in the fermentation process could inhibit the enzyme HMG-CoA-reductase, one of the main enzymes involved in the synthesis of cholesterol (which occurs in the liver). This metabolite was Monacolin K.

Plant-based statins, such as Monacolin K, have been shown to possess cholesterolaemic properties. Consumption must, however, comply with the recommended doses in order to avoid side effects such as weakness, muscle pain, gastrointestinal or liver disorders.

Olive extract promotes normal blood circulation and regularity of blood pressure. The Oleuropein contained in Coletix is represented by Olecol®, a patented, highly water-soluble, standardised Bioactor product, extracted from the olive leaf, with a very high concentration of bioavailable Oleuropine, which has been shown through a dual mechanism of action to promote normal blood circulation and regular blood pressure. It is a natural ingredient that offers a safe approach to managing blood lipid levels, which can increase levels of good cholesterol (HDL) and combat lipid oxidation, and whose validity has also been demonstrated in multiple randomised, placebo-controlled studies.

Gamma oryzanol is a substance that is extracted from rice bran oil; it is also present in wheat bran, some fruits and certain vegetables. Gamma oryzanol is believed to reduce cholesterol levels by limiting its absorption from food, which is why it is mainly proposed to treat cases where cholesterol is high. In particular, gamma oryzanol appears to reduce levels of total cholesterol, bad cholesterol (LDL, LowDensityLipoproteins) and triglyceride levels, as well as having metabolic, antioxidant and anti-inflammatory activities.

Coenzyme Q10, also known as ubiquinone due to its ubiquitous role in the body, is a very important molecule for our body. It is mainly present in the mitochondria, the energy stations of cells, and also in the heart muscle, although it is present in many human tissues. It is involved in the cell's electron transfer processes, and is a powerful antioxidant that protects membranes from oxidative damage. Since cholesterol-lowering statins also reduce the production of Coenzyme Q10, it is very useful to replenish levels of this substance when taking active ingredients, even natural ones, that could lower its physiological levels.

The synergistic combination of active ingredients contained in Coletix helps reduce cholesterol and triglyceride levels in the blood, supports heart health and blood pressure regularity and protects HDL (good) cholesterol by limiting the oxidation of LDL (bad) cholesterol and may help reduce the risk of cardiovascular events.

Scientific references

Özcan, M.M., Matthäus, B. A review: benefit and bioactive properties of olive (Olea europaea L.) leaves. Eur Food Res Technol 243, 89–99 (2017). https://doi.org/10.1007/s00217-016-2726-9

Lockyer S, Rowland I, Spencer JPE, Yaqoob P, Stonehouse W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr. 2017 Jun;56(4):1421-1432. doi: 10.1007/s00394-016-1188-y. Epub 2016 Mar 7. PMID: 26951205; PMCID: PMC5486627.

Stevens Y, Winkens B, Jonkers D, Masclee A. The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial. Eur J Nutr. 2021 Jun;60(4):2111-2120. doi: 10.1007/s00394-020-02397-9. Epub 2020 Oct 9. PMID: 33034707; PMCID: PMC8137474.

Lockyer S, Rowland I, Spencer JPE, Yaqoob P, Stonehouse W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr. 2017 Jun;56(4):1421-1432. doi: 10.1007/s00394-016-1188-y. Epub 2016 Mar 7. PMID: 26951205; PMCID: PMC5486627.

Mehmood A, Usman M, Patil P, Zhao L, Wang C. A review on management of cardiovascular diseases by olive polyphenols. Food Sci Nutr. 2020 Aug 13;8(9):4639-4655. doi: 10.1002/fsn3.1668. PMID: 32994927; PMCID: PMC7500788.

Cicero AFG, Fogacci F, Banach M. Red Yeast Rice for Hypercholesterolemia. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):192-199. doi: 10.14797/mdcj-15-3-192. PMID: 31687098; PMCID: PMC6822657.

Goufo P, Trindade H. Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sci Nutr. 2014 Mar;2(2):75-104. doi: 10.1002/fsn3.86. Epub 2014 Jan 21. PMID: 24804068; PMCID: PMC3959956.

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Nutritional information
Nutrition information Per daily dose (1 tablet)
Red yeast rice
of which monacolin K
58 mg
2,76 mg
Gamma oryzanolo (vegetable sterols 12%)
60 mg
Olive extract (Olecol®)
of which oleuropein
250 mg
80 mg
Coenzyme Q10
10 mg

bulking agent: cellulose, dicalcium phosphate; gamma oryzanol (plant sterols), olive extract (Olecol®) [(Olea europea L.) leaf, 32% oleuropein], fermented red rice (fermentation from Monascus purpureus on Oryza sativa L, seed) tit. 4.75% total monacolins, anti-caking agents: silicon dioxide, magnesium salts of fatty acids, stabiliser: cross-linked sodium carboxymethyl cellulose; coenzyme Q10.

Do not exceed the recommended daily dose. The supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children under three years of age. Per the use of the product it is advisable to hear the opinion of the doctor. Do not use during pregnancy, lactation and in case of therapy with hypolipidemic drugs. The product is not intended for people who do not need to control their blood cholesterol level. Avoid consuming more than 3 g/day of added plant sterols/plant stanols. Patients following a cholesterol-lowering treatment should only consume the product under medical supervision. The product should be taken as part of a varied and balanced diet, involving regular consumption of fruit and vegetables to help maintain carotenoid levels. The product may be nutritionally inappropriate for pregnant women, breastfeeding women and children under five years of age. Do not exceed the quantity equal to or greater than 3 mg of monacolins from red yeast rice per daily dose. It should not be consumed if other products containing red yeast rice are already consumed. Not to be consumed by pregnant or lactating women, children under 18 and adults over 70. Consult a physician about consuming this product if you experience any health problems. It should not be consumed if you are taking cholesterol-lowering medicines.
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Directions and intake
Take 1 tablet a day with water.
Our Advice

Coletix should preferably be taken close to meals. We recommend taking the daily tablet in the evening, before dinner, with a glass of water.

Frequently asked questions

Do supplements such as Coletix to lower cholesterol really work?

To reduce cholesterol levels in the blood, it is important first and foremost to eat a healthy, balanced diet and exercise, using food supplements as a lifestyle support. Some of the active ingredients contained in Coletix, such as Monacolin K from fermented red rice, Olecol® olive extract and gamma oryzanol have been shown to help reduce blood cholesterol levels by optimising control over blood lipid levels.

Can I take cholesterol medication and supplements at the same time?

It is always important to inform your doctor before taking food supplements, especially if you are already taking medication. Some of the natural extracts contained in Coletix may interact with cholesterol medications.

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Why choose it?

Why choose our product:

  • It participates in maintaining normal cholesterol and triglyceride levels in the blood;
  • It supports heart health and blood pressure regularity;
  • It supports carbohydrate and lipid metabolism;
  • It promotes glucose utilisation by muscle and liver cells;
  • 58mg of fermented red rice per tablet, titrated at 2.76% in Monacolin K, in compliance with current European regulations;
  • Olecol-certified raw material;
  • With added plant sterols and CoenzymeQ10;
  • Gluten- and lactose-free;
  • Ingredients of the highest quality and safety;
  • Produced entirely in Italy.
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Coletix - Sticky